Correlation of Tumor Location to Clinical Outcomes in Colorectal Cancer: A Single-institution Retrospective Analysis

被引：6
|
作者：
Signorelli, Carlo [1 ]
Chilelli, Mario Giovanni [1 ]
Sperduti, Isabella [2 ]
Giacinti, Silvana [1 ]
Amodio, Pietro Maria [3 ]
Palmieri, Raffaele Macarone [3 ]
Ranalli, Teresa Valentina [4 ]
Gomes, Vito Vincenzo [4 ]
Rosetto, Maria Elena [5 ]
Nelli, Fabrizio [1 ]
Ruggeri, Enzo Maria [1 ]
机构：
[1] Belcolle Hosp, ASL Viterbo, Med Oncol Unit, I-01100 Viterbo, Italy
[2] Regina Elena Inst Canc Res, Dept Biostat, Rome, Italy
[3] Belcolle Hosp, ASL Viterbo, Gen Oncol Surg, Viterbo, Italy
[4] Belcolle Hosp, ASL Viterbo, Pathol Unit, Viterbo, Italy
[5] Belcolle Hosp, ASL Viterbo, Radiotherapy Unit, Viterbo, Italy
来源：
ANTICANCER RESEARCH | 2019年 / 39卷 / 09期
关键词：
Tumor location; metastatic colorectal cancer; first-line therapy; SIDED COLON-CANCER; BEVACIZUMAB; CETUXIMAB; IMPACT;
D O I：
10.21873/anticanres.13679
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Recent data highlighted that location of metastatic colorectal cancer (mCRC) may have a prognostic impact and also a predictive value of the outcomes of first-line therapy. Materials and Methods: The records of mCRC patients who underwent first-line therapy from 2011 to April 2018 at our Institute were retrospectively reviewed. Progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) according to the primary tumor location were investigated. Results: Overall, 130 patients were eligible. Two-year OS was 82.9% in left-sided colon cancers (LCC) and 67.5% in right-sided (RCC) (p=0.32). One-year mPFS was statistically longer in LCC (46.8% vs. 24.2%, p=0.0005). mPFS was longer in LCC treated with anti-VEGF vs. anti-EGFR (p=0.06). ORR was 51.1% in LCC, 25% in RCC (p=0.008). Overall, 11 complete responses all in LCC were observed (p=0.03). Conclusion: Tumor location has a prognostic impact and might influence the outcomes of mCRC patients.
引用
收藏
页码：4917 / 4924
页数：8
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