Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer

被引：2
|
作者：
Ruan, Jiaying [1 ]
Mei, Ling [1 ]
Zhu, Qian [1 ]
Shi, Gang [1 ]
Wang, He [1 ]
机构：
[1] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 11期
关键词：
Cervical squamous cell carcinoma; MLKL; phosphorylate; immunohistochemistry; NECROSIS; DOWNSTREAM; EXPRESSION; DEATH; RIP3;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumor necrosis factor (TNF)-induced necroptosis. Objective: To evaluate the expression and clinical significance of MLKL in cervical squamous cell carcinoma. Methods: The expression of MLKL in 54 cervical squamous carcinoma samples was detected by immuneohistochemical method. Chi-square, correlation analysis and kaplan-Meier method were used to analyze the data. Results: The MLKL expression in cervical squamous cell carcinoma was higher than that in normal cervical tissues (P = 0.004). The MLKL expression was negatively correlated with histological grade, lymphatic metastasis (P< 0.05). Survival analysis showed the low expression of MLKL indicated poor prognosis. Conclusion: MLKL was a prognostic biomarker for cervical squamous cell carcinoma.
引用
收藏
页码：15035 / 15038
页数：4
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