Preparation of (2,3-Dihydrobenzofuran-3-yl)acetic Acid via Rh-Catalyzed Asymmetric Hydrogenation

被引：10

作者：

Yamashita, Masayuki ^{[1
]}

Negoro, Nobuyuki ^{[2
]}

Yasuma, Tsuneo ^{[1
]}

Yamano, Toru ^{[3
]}

机构：

[1] Takeda Pharmaceut Co Ltd, CMC Ctr, Chem Dev Labs, Yodogawa Ku, Osaka 5328686, Japan

[2] Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Fujisawa, Kanagawa 2518555, Japan

[3] Takeda Pharmaceut Co Ltd, Environm & Safety Dept, Yodogawa Ku, Osaka 5328686, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2014年 / 87卷 / 04期

关键词：

CHIRAL PHOSPHORUS LIGANDS; ENANTIOSELECTIVE HYDROGENATION; DERIVATIVES; AGONISTS; DISCOVERY; OLEFINS; POTENT;

D O I：

10.1246/bcsj.20130324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A preparation via Rh-catalyzed asymmetric hydrogenation has been developed for (2,3-dihydrobenzofuran-3-yl)acetic acid derivatives, a key intermediate in the synthesis of the active pharmaceutical ingredient for GPR40 agonist, fasiglifam. Use of a cationic rhodium-Et-FerroTANE complex yielded the desired product in high enantiomeric excess (91%) and quantitative yield, and was thus recommended for further process development.

引用

页码：539 / 543

页数：5

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