Liposomal amphotericin B for treatment of visceral leishmaniasis: results of a pilot study on 98 immunocompetent children

被引：0
|
作者：
DiMartino, L
Castagnola, E
Giacchino, R
Tasso, L
Scotti, S
Raimondi, F
Mantovani, MP
Cascio, A
Gradoni, L
Scalone, A
Davidson, RN
机构：
[1] IST GIANNINA GASLINI,DIV MALATTIE INFETT,I-16148 GENOA,ITALY
[2] UNIV NAPLES FEDERICO II,DIPARTIMENTO PEDIAT,NAPLES,ITALY
[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,BRONX,NY 10461
[4] UNIV PALERMO,CLIN MALATTIE INFETT,I-90133 PALERMO,ITALY
[5] IST SUPER SANITA,LAB PARASSITOL,I-00161 ROME,ITALY
[6] NORTHWICK PK HOSP & CLIN RES CTR,LISTER INST INFECT & TROP DIS,LONDON,ENGLAND
来源：
RIVISTA ITALIANA DI PEDIATRIA-ITALIAN JOURNAL OF PEDIATRICS | 1997年 / 23卷 / 02期
关键词：
visceral leishmaniasis; pediatrics; liposomal amphotencin B;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Liposomal amphotericin B was administered as treatment of visceral leishmaniasis to 98 immunocompetent children according to different schedules: 11 were treated with a total dose of 21 mg/kg, 13 (8 first diagnoses and 5 relapses) with a total dose of 30 mg/kg, 63 with a total dose of 18 mg/kg and 16 with a total dose of 15 mg/kg. Five episodes of relapse were observed within 4 months after the end of treatment: 1 in the group created with 18 mg/kg and 4 in the group treated with 15 mg/kg. All relapses were treated successfully, with a total dose of 30 mg/kg. The only side effects reported was ipokalemia in 24/103 (23%) administered cycles. In conclusion liposomal amphotericin B is effective and safe for treatment of visceral leishmania in immunocompetent children.
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收藏
页码：241 / 244
页数：4
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