New Biologically Active Hydrogen Sulfide Donors

被引：62
|
作者：
Roger, Thomas [1 ]
Raynaud, Francoise [1 ]
Bouillaud, Frederic [2 ]
Ransy, Celine [2 ]
Simonet, Serge [3 ]
Crespo, Christine [3 ]
Bourguignon, Marie-Pierre [3 ]
Villeneuve, Nicole [3 ]
Vilaine, Jean-Paul [3 ]
Artaud, Isabelle [1 ]
Galardon, Erwan [1 ]
机构：
[1] Univ Paris 05, PRES Sorbonne Paris Cite, CNRS, LCBPT,UMR 8601, F-75006 Paris, France
[2] Univ Paris 05, PRES Sorbonne Paris Cite, CNRS UMR 8104, Inst Cochin,Inserm U1016, F-75014 Paris, France
[3] Inst Rech SERVIER, Unite Cardiovasc, F-92150 Suresnes, France
来源：
CHEMBIOCHEM | 2013年 / 14卷 / 17期
关键词：
biological activity; dithioperoxyanhydrides; hydrogen sulfide; oxidoreductases; SQR; vasorelaxation; LYSINE ACETYLATION; FLUORESCENT-PROBES; H2S; SULFUR; SULFHYDRATION; VASOACTIVITY; METABOLISM; OXIDATION; BIOLOGY; TISSUES;
D O I：
10.1002/cbic.201300552
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Generous donors: The dithioperoxyanhydrides (CH3COS) 2, (PhCOS)2, CH3COSSCO2Me and PhCOSSCO2Me act as thiol-activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex vivo vascular studies. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2268 / 2271
页数：4
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