Glucocorticoid receptor dynamics and gene regulation

被引：55
|
作者：
Biddie, Simon C. [1 ,2 ]
Hager, Gordon L. [1 ]
机构：
[1] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA
[2] Univ Bristol, Dept Med, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England
来源：
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2009年 / 12卷 / 03期
关键词：
Glucocorticoid receptor; chromatin; dynamics; gene expression; TUMOR VIRUS PROMOTER; NF-KAPPA-B; LONG TERMINAL REPEAT; ESTROGEN-RECEPTOR; IN-VIVO; TRANSCRIPTIONAL ACTIVATION; TRANSACTIVATION DOMAIN; MOLECULAR CHAPERONE; CHROMATIN DYNAMICS; ANDROGEN RECEPTOR;
D O I：
10.1080/10253890802506409
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The glucocorticoid receptor regulates the expression of a large number of genes in mammalian cells. The interaction of this receptor with regulatory elements has been discovered to be highly dynamic, with occupancy states measured in seconds, rather than minutes or hours. This finding has led to a paradigm shift in our understanding of receptor function throughout the genome. The mechanisms involved in these rapid exchange events, as well as the implications for receptor function, are discussed.
引用
收藏
页码：193 / 205
页数：13
相关论文
共 50 条
  • [21] Redox Regulation of the Glucocorticoid Receptor
    Tanaka, Hirotoshi
    Makino, Yuichi
    Okamoto, Kensaku
    Iida, Takahisa
    Yan, Kunimasa
    Yoshikawa, Noritada
    ANTIOXIDANTS & REDOX SIGNALING, 1999, 1 (04) : 403 - 423
  • [22] INVOLVEMENT OF GLUCOCORTICOID RECEPTOR AND PREGNANE X RECEPTOR IN THE REGULATION OF MOUSE CYP3A44 GENE EXPRESSION BY GLUCOCORTICOID HORMONE
    Bhadhprasit, Wattanaporn
    Sakuma, Tsutomu
    Nemoto, Nobuo
    DRUG METABOLISM REVIEWS, 2007, 39 : 334 - 334
  • [23] Folding of the glucocorticoid receptor N-terminal transactivation function: Dynamics and regulation
    Kumar, R.
    Thompson, E. B.
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 348 (02) : 450 - 456
  • [24] Multiple domains of melatonin receptor are involved in the regulation of glucocorticoid receptor-induced gene expression
    Persengiev, SP
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1999, 68 (5-6): : 181 - 187
  • [25] Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor
    So, Alex Yick-Lun
    Chaivorapol, Christina
    Bolton, Eric C.
    Li, Hao
    Yamamoto, Keith R.
    PLOS GENETICS, 2007, 3 (06): : 927 - 938
  • [26] Evidence for glucocorticoid regulation of the rat vasopressin V-1a receptor gene
    Watters, JJ
    Swank, MW
    Wilkinson, CW
    Dorsa, DM
    PEPTIDES, 1996, 17 (01) : 67 - 73
  • [27] Selective gene regulation by glucocorticoid receptor translational isoforms in T cells.
    Shin, Soon Cheon
    Schleimer, Robert
    Lu, Nick
    JOURNAL OF IMMUNOLOGY, 2011, 186
  • [28] Glucocorticoid regulation of the vitamin D receptor
    Hidalgo, Alejandro A.
    Trump, Donald L.
    Johnson, Candace S.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 121 (1-2): : 372 - 375
  • [29] Selenoprotein P regulation by the glucocorticoid receptor
    Colleen Rock
    Philip J. Moos
    BioMetals, 2009, 22 : 995 - 1009
  • [30] Regulation of triglyceride metabolism by glucocorticoid receptor
    Jen-Chywan Wang
    Nora E Gray
    Taiyi Kuo
    Charles A Harris
    Cell & Bioscience, 2
12345