Amino acid chirons: a tool for asymmetric synthesis of heterocycles

被引：59

作者：

Singh, Priyanka ^{[1
]}

Samanta, Krishnananda ^{[1
]}

Das, Sanjit Kumar ^{[1
]}

Panda, Gautam ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 33期

关键词：

ONE-POT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; CONFORMATIONAL MIMICRY; ENANTIODIVERGENT SYNTHESIS; ENANTIOSPECIFIC SYNTHESIS; MORPHOLINE DERIVATIVES; REDUCTIVE CYCLIZATION; BIOLOGICAL EVALUATION;

D O I：

10.1039/c4ob00943f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a result of their easy availability in enantiomerically enriched form and their possession of synthetically transformable diverse functional groups, amino acids have been extensively used by synthetic organic and medicinal chemists as a chiral pool for access to heterocycles (monocycles, bicycles or polycycles, either bridged or fused). This review describes the syntheses of diverse asymmetric heterocycles with various membered rings (n = 3-9) followed by benzo or heteroannulated ones, for the period from 1996 to Dec. 2013. It details solution phase synthetic methodologies in which the naturally occurring alpha-amino acid is incorporated, totally or partially, into the final product.

引用

页码：6297 / 6339

页数：43

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