Ionic-liquid-supported organocatalyst: Efficient and recyclable ionic-liquid-anchored proline for asymmetric aldol reaction

被引：178
|
作者：
Miao, Weishi [1 ]
Chan, Tak Hang [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 12-13期
关键词：
asymmetric aldol reactions; catalysis; ionic liquids; proline; supported synthesis;
D O I：
10.1002/adsc.200606059
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Ionic-liquid-anchored (2S,4R)-4-hydroxyproline 12 catalyzes direct asymmetric aldol reactions with comparable enantioselectivities in DMSO, and with superior enantioselectivities in neat acetone or 2-butanone, than (S)-proline (8) (up to 28% ee difference) itself. Furthermore, the supported catalyst 12 can be easily recycled and reused for at least four times without significant loss of yields and enantioselectivity.
引用
收藏
页码：1711 / 1718
页数：8
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