Biopharmaceutical formulation

被引：19
|
作者：
Lee, JC [1 ]
机构：
[1] Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77555 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0958-1669(99)00058-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The rapid maturation of the field of biopharmaceutical formulation is the result of the simultaneous development of a thermodynamic mechanism for protein-solvent interaction and identification of natural chemicals employed by nature to stabilize proteins in response to environmental stresses. In general, these cosolvents are excluded from the protein surface. Proteins are maintained in their native folded conformations by these cosolvents as a result of the highly unfavorable interaction between cosolvents and peptide backbones, which would be exposed to the cosolvent upon unfolding.
引用
收藏
页码：81 / 84
页数：4
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