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Guangdong Acad Med Sci, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangdong Cardiovasc Inst, Dept Cardiol,Guangdong Prov Peoples Hosp, Guangzhou 510100, Peoples R China Guangdong Acad Med Sci, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangdong Cardiovasc Inst, Dept Cardiol,Guangdong Prov Peoples Hosp, Guangzhou 510100, Peoples R China