Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod

被引：3
|
作者：
Fukai, Ryoko [1 ]
Takahashi, Keita [1 ]
Abet, Hiroyuki [2 ]
Higashiyama, Yuichi [1 ]
Doi, Hiroshi [1 ]
Takeuchi, Hideyuki [1 ]
Tanaka, Fumiaki [1 ]
机构：
[1] Yokohama City Univ, Grad Sch Med, Dept Neurol & Stroke Med, Yokohama, Kanagawa, Japan
[2] Yokohama City Univ, Grad Sch Med, Dept Neurosurg, Yokohama, Kanagawa, Japan
来源：
FRONTIERS IN NEUROLOGY | 2019年 / 10卷
基金：
日本学术振兴会;
关键词：
epidural hematoma; fingolimod; multiple sclerosis; sphingosine-1-phosphate receptor; vascular disruption; FTY720;
D O I：
10.3389/fneur.2019.00763
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fingolimod acts as a functional antagonist of the sphingosine-1 -phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption. Switching fingolimod to other disease-modifying drugs, including dimethyl fumarate, should be considered when non-traumatic hemorrhage is observed in MS patients.
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页数：4
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