COVID-19;
vaccine;
drug discovery;
hrsACE2;
ivermectin;
famotidine;
PNEUMONIA;
D O I:
10.3934/molsci.2020013
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
All species of coronavirus may cause infections in birds which is known to us since the 60s, but recently, from Nov 2019, the disease emerged in humans from the seafood market in Wuhan city. The previous viral outbreaks like SARS-CoV and MERS-CoV have also shown a greater mortality rate when transmitted to humans than other animals. An emerging concern in the 2019 novel coronavirus (SARS-CoV-2) is in terms of developing vaccine or discovery of new drugs to overcome the current viral pandemic. In this rapid-review, we aim to update the available data on coronavirus with the latest findings and achievements. So far, great steps have been taken such as hrsACE2 by a Swedish team from Karolinska Institute. Monash University announced the efficacy of Ivermectin to overcome COVID-19. The CRISPR/Cas13d as a new innovative therapeutics based might overcome the challenge of COVID-19. those strains of virus which lacking E protein-encoding regions are the perfect choice for vaccine development.
机构:
Operation Management Office, West China Second University Hospital, ChengduOperation Management Office, West China Second University Hospital, Chengdu
Xu S.
Tang D.
论文数: 0引用数: 0
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机构:
Department of Urology, West China Hospital of Sichuan University, ChengduOperation Management Office, West China Second University Hospital, Chengdu
机构:
Univ Tokyo, Inst Med Sci, Ctr Gene & Cell Therapy, Div Mol & Med Genet, Minato Ku, Tokyo 1088639, Japan
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Adm Sect Radiat Protect, Kodaira, Tokyo 1878551, JapanUniv Tokyo, Inst Med Sci, Ctr Gene & Cell Therapy, Div Mol & Med Genet, Minato Ku, Tokyo 1088639, Japan
Matsuzaka, Yasunari
Yashiro, Ryu
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机构:
Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Adm Sect Radiat Protect, Kodaira, Tokyo 1878551, Japan
Kyorin Univ, Dept Infect Dis, Sch Med, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, JapanUniv Tokyo, Inst Med Sci, Ctr Gene & Cell Therapy, Div Mol & Med Genet, Minato Ku, Tokyo 1088639, Japan
机构:
Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R China
Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 3, Ruian, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Dong, Yetian
Dai, Tong
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机构:
Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China
Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Dai, Tong
Wang, Bin
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机构:
Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Wang, Bin
Zhang, Lei
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机构:
Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 3, Ruian, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Zhang, Lei
Zeng, Ling-Hui
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机构:
Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Zeng, Ling-Hui
Huang, Jun
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机构:
Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Huang, Jun
Yan, Haiyan
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h-index: 0
机构:
Zhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Yan, Haiyan
Zhang, Long
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
Zhang, Long
Zhou, Fangfang
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机构:
Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China
Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R ChinaZhejiang Univ City Coll, Sch Med, Hangzhou 310015, Zhejiang, Peoples R China
机构:
Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University
Rong Li
Jun Liu
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机构:
Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University
Jun Liu
Hui Zhang
论文数: 0引用数: 0
h-index: 0
机构:
Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen UniversityInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University
机构:
Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Technol, Jeddah, Saudi ArabiaDrexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
Alturki, Sana O.
Alturki, Sawsan O.
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机构:
Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Technol, Jeddah, Saudi ArabiaDrexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
Alturki, Sawsan O.
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机构:
Connors, Jennifer
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机构:
Cusimano, Gina
Kutzler, Michele A.
论文数: 0引用数: 0
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机构:
Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
Drexel Univ, Coll Med, Dept Med, Div Infect Dis & HIV Med, Philadelphia, PA 19104 USADrexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
Kutzler, Michele A.
Izmirly, Abdullah M.
论文数: 0引用数: 0
h-index: 0
机构:
Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Technol, Jeddah, Saudi Arabia
Drexel Univ, Coll Med, Dept Med, Div Infect Dis & HIV Med, Philadelphia, PA 19104 USADrexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
Izmirly, Abdullah M.
Haddad, Elias K.
论文数: 0引用数: 0
h-index: 0
机构:
Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA
Drexel Univ, Coll Med, Dept Med, Div Infect Dis & HIV Med, Philadelphia, PA 19104 USADrexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA