Connectivity is an important index in evaluating the reliability and fault tolerant ability of interconnection network. However the traditional connectivity is inappropriate for large scale multiprocessor systems. The h-restricted connectivity, as a generalization of traditional connectivity, was proposed to estimate the reliability of interconnection networks more accurately. For an interconnection network G and a positive integer h, the cardinality of a vertex subset F is called the h-restricted connectivity of G, denoted kappa(h)(G), if F is the minimum vertex set subject to that G - F is disconnected and delta(G - F) >= h. In this paper, we investigate the h-restricted connectivity of the generalized hypercube G(m(r),m(r-1), ..., m(1)). Specially, we determine that kappa(h)(G(m(r),m(r-1), ..., m(1))) = (h + 1)kappa (G(m(r), m(r-1), ..., m(1))) - mmaxh for 1 < h < min{left perpendicular mr/2 - 1, m(min) - 1, r}, where kappa (G(m(r), m(r-1), ..., m(1))) is the connectivity of the generalized hypercube, mmax = max{m(r), m(r-1), ..., m(1)} and m(min) = min{m(r), m(r-1), ..., m(1)}. (C) 2020 Elsevier B.V. All rights reserved.