Chiral inversion and enantioselective active metabolite formation of prasugrel, a novel thienopyridine antiplatelet agent, in dogs

被引:0
|
作者
Takahashi, Makoto
Kawabata, Kiyoshi
Kurihara, Atsushi
Ikeda, Toshihiko
Sone, Junko
Farid, Nagy A.
机构
[1] Sankyo Co Ltd, Drug Metab & Pharmacokinet Res Labs, Tokyo 140, Japan
[2] Sankyo Co Ltd, Core Technol Res Labs, Tokyo 140, Japan
[3] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
141
引用
收藏
页码:88 / 89
页数:2
相关论文
共 50 条
  • [21] Identification of the cytochromes P450 responsible for the formation of R-138727, the active metabolite of a novel thienopyridine anti-platelet agent, CS-747 (LY640315)
    Fayer, JL
    Eckstein, JA
    Kasper, SC
    Farid, NA
    Wrighton, SA
    Kurihara, A
    Ring, BJ
    DRUG METABOLISM REVIEWS, 2004, 36 : 342 - 342
  • [22] Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type Gi-linked P2T antagonist, CS-747
    Sugidachi, A
    Asai, F
    Yoneda, K
    Iwamura, R
    Ogawa, T
    Otsuguro, K
    Koike, H
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 132 (01) : 47 - 54
  • [23] A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation
    Brandt, John T.
    Payne, Christopher D.
    Wiviott, Stephen D.
    Weerakkody, Govinda
    Farid, Nagy A.
    Small, David S.
    Jaknbowski, Joseph A.
    Naganuma, Hideo
    Winters, Kenneth J.
    AMERICAN HEART JOURNAL, 2007, 153 (01) : 66.e9 - 66.e16
  • [24] Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel
    Payne, Christopher D.
    Li, Ying Grace
    Small, David S.
    Ernest, C. Steven, II
    Farid, Nagy A.
    Jakubowski, Joseph A.
    Brandt, John T.
    Salazar, Daniel E.
    Winters, Kenneth J.
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2007, 50 (05) : 555 - 562
  • [25] Prasugrel (CS-747, LY640315) hydrochloride, a novel thienopyridine prodrug, shows potent antiplatelet and antithrombotic effects with rapid onset of action in rats.
    Niitsu, Y
    Ogawa, T
    Sugidachi, A
    Jakubowski, JA
    Yokouchi, Y
    Kakusaka, M
    Hasegawa, M
    Asai, F
    BLOOD, 2005, 106 (11) : 534A - 534A
  • [26] In vitro effects of Prasugrel's active metabolite on a novel ELISA-based whole blood VASP assay
    Yamaguchi, S.
    Ohno, K.
    Jakubowski, J. A.
    Tomizawa, A.
    Sugidachi, A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 532 - 532
  • [27] Synthesis of a novel cage-functionalized chiral binaphthol host: a potential new agent for enantioselective recognition of chiral ammonium salts
    Marchand, AP
    Chong, HS
    Ganguly, B
    TETRAHEDRON-ASYMMETRY, 1999, 10 (24) : 4695 - 4700
  • [28] Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response
    Backman, Joshua D.
    O'Connell, Jeffrey R.
    Tanner, Keith
    Peer, Cody J.
    Figg, William D.
    Spencer, Shawn D.
    Mitchell, Braxton D.
    Shuldiner, Alan R.
    Yerges-Armstrong, Laura M.
    Horenstein, Richard B.
    Lewis, Joshua P.
    PHARMACOGENETICS AND GENOMICS, 2017, 27 (04): : 159 - 163
  • [29] Enantioselective determination of the novel antidepressant mirtazapine and its active demethylated metabolite in human plasma by means of capillary electrophoresis
    Mandrioli, R
    Pucci, V
    Sabbioni, C
    Bartoletti, C
    Fanali, S
    Raggi, MA
    JOURNAL OF CHROMATOGRAPHY A, 2004, 1051 (1-2) : 253 - 260
  • [30] DICENTRINE, A NOVEL ANTIPLATELET AGENT INHIBITING THROMBOXANE FORMATION AND INCREASING THE CYCLIC-AMP LEVEL OF RABBIT PLATELETS
    YU, SM
    CHEN, CC
    KO, FN
    HUANG, YL
    HUANG, TF
    TENG, CM
    BIOCHEMICAL PHARMACOLOGY, 1992, 43 (02) : 323 - 329