Chiral inversion and enantioselective active metabolite formation of prasugrel, a novel thienopyridine antiplatelet agent, in dogs

被引：0
|
作者：
Takahashi, Makoto
Kawabata, Kiyoshi
Kurihara, Atsushi
Ikeda, Toshihiko
Sone, Junko
Farid, Nagy A.
机构：
[1] Sankyo Co Ltd, Drug Metab & Pharmacokinet Res Labs, Tokyo 140, Japan
[2] Sankyo Co Ltd, Core Technol Res Labs, Tokyo 140, Japan
[3] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
来源：
DRUG METABOLISM REVIEWS | 2006年 / 38卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
141
引用
收藏
页码：88 / 89
页数：2
相关论文
共 50 条
  • [1] Biotransformation of Prasugrel, a Novel Thienopyridine Antiplatelet Agent, to the Pharmacologically Active Metabolite
    Hagihara, Katsunobu
    Kazui, Miho
    Kurihara, Atsushi
    Iwabuchi, Haruo
    Ishikawa, Minoru
    Kobayashi, Hiroyuki
    Tanaka, Naoki
    Okazaki, Osamu
    Farid, Nagy A.
    Ikeda, Toshihiko
    DRUG METABOLISM AND DISPOSITION, 2010, 38 (06) : 898 - 904
  • [2] Glutaredoxin and Thioredoxin Can Be Involved in Producing the Pharmacologically Active Metabolite of a Thienopyridine Antiplatelet Agent, Prasugrel
    Hagihara, Katsunobu
    Kazui, Miho
    Kurihara, Atsushi
    Kubota, Kazuishi
    Ikeda, Toshihiko
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (02) : 208 - 214
  • [3] A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel
    Hagihara, Katsunobu
    Kazui, Miho
    Kurihara, Atsushi
    Yoshiike, Michiharu
    Honda, Kokichi
    Okazaki, Osamu
    Farid, Nagy A.
    Ikeda, Toshihiko
    DRUG METABOLISM AND DISPOSITION, 2009, 37 (11) : 2145 - 2152
  • [4] Prasugrel: A novel antiplatelet agent
    Riley, Amy B.
    Tafreshi, Mohammad J.
    Haber, Stacy L.
    AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2008, 65 (11) : 1019 - 1028
  • [5] Potent inhibition of platelet aggregation by prasugrel (CS-747, LY640315), a novel thienopyridine antiplatelet agent, is associated with covalent binding of active metabolite to ADP receptor
    Kurihara, A.
    Kazui, M.
    Hagihara, K.
    Isobe, T.
    Ogawa, T.
    Sugidachi, A.
    Farid, N. A.
    Ikeda, T.
    EUROPEAN HEART JOURNAL, 2005, 26 : 485 - 485
  • [6] Prasugrel: A novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile
    Jakubowski, Joseph A.
    Winters, Kenneth J.
    Naganuma, Hideo
    Wallentin, Lars
    CARDIOVASCULAR DRUG REVIEWS, 2007, 25 (04): : 357 - 374
  • [7] Direct evidence for binding of the active metabolite of prasugrel (CS-747, LY640315), a novel thienopyridine antiplatelet drug, to human platelets
    Ogawa, T.
    Isobe, T.
    Sugidachi, A.
    Niitsu, Y.
    Hagihara, K.
    Kurihara, A.
    Jakubowski, J. A.
    Asai, F.
    EUROPEAN HEART JOURNAL, 2006, 27 : 757 - 757
  • [8] Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
    Rehmel, JLF
    Eckstein, JA
    Farid, NA
    Heim, JB
    Kasper, SC
    Kurihara, A
    Wrighton, SA
    Ring, BJ
    DRUG METABOLISM AND DISPOSITION, 2006, 34 (04) : 600 - 607
  • [9] Integrated Analysis of Pharmacokinetic Data Across Multiple Clinical Pharmacology Studies of Prasugrel, a New Thienopyridine Antiplatelet Agent
    Small, David S.
    Li, Ying G.
    Ernest, C. Steven, II
    April, John H.
    Farid, Nagy A.
    Payne, Christopher D.
    Winters, Kenneth J.
    Rohatagi, Shashank
    Ni, Lan
    JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 51 (03): : 321 - 332
  • [10] The Intestine As an Important Contributor to Prasugrel Active Metabolite Formation In Vivo
    Hagihara, Katsunobu
    Kazui, Miho
    Ikenaga, Hidenori
    Nanba, Toshihiko
    Fusegawa, Kiichi
    Izumi, Takashi
    Ikeda, Toshihiko
    Kurihara, Atsushi
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (04) : 565 - 570
12345