Serum concentrations of interleukin-2 and tumour necrosis factor-α under cyclosporine versus acitretin treatment in plaque-type psoriasis

被引：12
|
作者：
Akcali, Cenk [1 ]
Guven, Ebru Homurlu [2 ]
Kirtak, Necmettin [1 ]
Inaloz, H. Serhat [1 ]
Ozgoztasi, Orhan [1 ]
Guvenc, Ulas [3 ]
机构：
[1] Gaziantep Univ, Fac Med, Dept Dermatol, TR-27070 Gaziantep, Turkey
[2] Avukat Cengiz Gokcek State Hosp, Dept Dermatol, Gaziantep, Turkey
[3] Med Pk Hosp, Dermatol Clin, Tarsus, Turkey
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2014年 / 42卷 / 05期
关键词：
Psoriasis; cyclosporine; acitretin; interleukin-2 (IL-2); tumour necrosis factor-alpha (TNF-alpha); ETRETINATE; THERAPY; MULTICENTER; ACTIVATION; TRIAL; SKIN;
D O I：
10.1177/0300060514539280
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: A prospective, randomized clinical study to compare the short-term effects of cyclosporin and acitretin on psoriasis severity, and serum interleukin (IL)-2 and tumour necrosis factor (TNF)-alpha concentrations. Methods: Patients with moderate-to-severe plaque-type psoriasis were randomly assigned to receive either 3 mg/kg per day cyclosporine or 0.3-0.5 mg/kg per day acitretin for 8 weeks. Disease severity (psoriasis area severity index [PASI] score) and serum IL-2 and TNF-alpha concentrations were determined before and after treatment. Results: PASI scores and serum IL-2 and TNF-alpha concentrations were significantly decreased after treatment with either cyclosporine (n = 21) or acitretin (n = 25). There were no statistically significant between-group differences in any parameter. Conclusions: Acitretin and cyclosporine are equally effective in the treatment of moderate-to-severe plaque-type psoriasis.
引用
收藏
页码：1118 / 1122
页数：5
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