Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

被引：8

作者：

Grassin-Delyle, Stanislas ^{[1
,2
]}

Salvator, Helene ^{[1
,3
]}

Brollo, Marion ^{[3
]}

Catherinot, Emilie ^{[1
]}

Sage, Edouard ^{[1
,4
]}

Couderc, Louis-Jean ^{[1
,3
]}

Naline, Emmanuel ^{[1
,3
]}

Devillier, Philippe ^{[1
,3
]}

机构：

[1] Foch Hosp, Dept Resp Dis, Suresnes, France

[2] Univ Paris Saclay, Dept Biotechnol Sante, INSERM Infect & Inflammat, Montigny Le Bretonneux, France

[3] Univ Paris Saclay, Foch Hosp, Lab Res Resp Pharmacol, Exhal Facil, Suresnes, France

[4] Univ Paris Saclay, INRAE, UMR0892, Jouy En Josas, France

来源：

CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 16期

关键词：

chloroquine; lung explant; tumor necrosis factor-alpha; interleukin-6; chemokine; COVID-19; STORM;

D O I：

10.1093/cid/ciaa546

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 mu M) inhibited the lipopolysaccharide-induced release of TNF-alpha (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.

引用

页码：2265 / 2268

页数：4

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