Chloroquine Inhibits the Release of Inflammatory Cytokines by Human Lung Explants

被引：8
|
作者：
Grassin-Delyle, Stanislas [1 ,2 ]
Salvator, Helene [1 ,3 ]
Brollo, Marion [3 ]
Catherinot, Emilie [1 ]
Sage, Edouard [1 ,4 ]
Couderc, Louis-Jean [1 ,3 ]
Naline, Emmanuel [1 ,3 ]
Devillier, Philippe [1 ,3 ]
机构：
[1] Foch Hosp, Dept Resp Dis, Suresnes, France
[2] Univ Paris Saclay, Dept Biotechnol Sante, INSERM Infect & Inflammat, Montigny Le Bretonneux, France
[3] Univ Paris Saclay, Foch Hosp, Lab Res Resp Pharmacol, Exhal Facil, Suresnes, France
[4] Univ Paris Saclay, INRAE, UMR0892, Jouy En Josas, France
来源：
CLINICAL INFECTIOUS DISEASES | 2020年 / 71卷 / 16期
关键词：
chloroquine; lung explant; tumor necrosis factor-alpha; interleukin-6; chemokine; COVID-19; STORM;
D O I：
10.1093/cid/ciaa546
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 mu M) inhibited the lipopolysaccharide-induced release of TNF-alpha (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by coronaviruses.
引用
收藏
页码：2265 / 2268
页数：4
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