Cancer chemopreventive activity of serratane-type triterpenoids from Picea jezoensis

被引：12
|
作者：
Tanaka, R
Minami, T
Ishikawa, Y
Tokuda, H
Matsunaga, S
机构：
[1] Osaka Univ Pharmaceut Sci, Dept Med Chem, Takatsuki, Osaka 5691094, Japan
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
CHEMISTRY & BIODIVERSITY | 2004年 / 1卷 / 06期
关键词：
D O I：
10.1002/cbdv.200490070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To search for cancer chemopreventive agents from natural sources, 13alpha,14alpha-epoxy-21alpha-methoxyserratan-3one, 21alpha-methoxyserrat-13-en-3-one, and 21alpha-hydroxy-3beta-methoxyserrat-14-en-30-al isolated from the cuticle of Picea jezoensis (SIEB. et Zucc.) CARR. var jezoensis (Pinaceae) were investigated for inhibitory effects in a two-stage mouse skin carcinogenesis test on mouse skin with 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as promoter. 21alpha-hydroxy-3beta-methoxyserrat-14-en-30-al and 13a,14a-epoxy-2la-methoxyserratan-3-one were found to exhibit strong antitumor-promoting activities in the in vivo carcinogenesis test.
引用
收藏
页码：878 / 885
页数：8
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