Familial lung cancer risk among women in Poland

被引：13

作者：

Rachtan, Jadwiga ^{[1
]}

Sokolowski, Andrzej ^{[1
,2
]}

Niepsuj, Stanislaw ^{[3
]}

Zemla, Brunon ^{[4
]}

Zwierko, Maria ^{[5
]}

机构：

[1] M Sklodowska Curie Mem Inst, Epidemiol Unit, Ctr Oncol, PL-31115 Krakow, Poland

[2] Cracow Univ Econ, Dept Stat, PL-31510 Krakow, Poland

[3] Pulmonol & Oncol Ctr, PL-10357 Olsztyn, Poland

[4] M Sklodowska Curie Mem Inst, Dept Canc Epidemiol, Ctr Oncol, PL-44101 Gliwice, Poland

[5] M Sklodowska Curie Mem Inst, Independent Unit Warsaw Canc Registry, Ctr Oncol, PL-02781 Warsaw, Poland

来源：

LUNG CANCER | 2009年 / 65卷 / 02期

关键词：

Lung cancer; Women; Familial aggregation; Smoking; Case-control study; Epidemiology; HISTOLOGIC TYPE; HISTORY; AGGREGATION; NONSMOKERS; RELATIVES; PROBANDS; SMOKERS;

D O I：

10.1016/j.lungcan.2008.10.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A case-control study involving 1058 women with histologically confirmed lung cancer and 2116 healthy controls, was conducted in Poland between 2004 and 2007. The aim of this study was to examine of the role of familial aggregation of lung cancer in women. Multivariate analysis has shown that family history of lung cancer in a first-degree relative significantly increases the risk of lung cancer (OR = 1.61, p = 0.0003). For cases with early onset of the disease (<55 years) we observed significantly elevated risk of lung cancer (OR=2.48, p=0.0001). Results of our analysis confirmed synergistic influence of smoking and family history of lung cancer (OR = 12.91, p = 0.0000). (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：138 / 143

页数：6

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