Genetic analysis for JNK-mediated apoptosis

被引:2
|
作者
Kuranaga, E [1 ]
Miura, M [1 ]
机构
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Genet, Bunkyo Ku, Tokyo 1130033, Japan
关键词
JNK; IAPs; ASK1; TRAFs; apoptosis;
D O I
10.1267/ahc.37.223
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Recent genetic studies revealed crucial roles of JNK (c-jun N-terminal kinase) activation in cell death. However, the molecular mechanisms underlying JNK-mediated cell death are largely unknown. We present one of the JNK-mediated apoptotic mechanism is regulated by a ubiquitine-proteasome system.
引用
收藏
页码:223 / 226
页数:4
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