The apparent antipsychotic action of the 5-HT2a receptor antagonist M100907 in a mouse model of schizophrenia is counteracted by ritanserin - Rapid communication

被引：37
|
作者：
Martin, P
Waters, N
Carlsson, A
Carlsson, ML
机构：
[1] Department of Pharmacology, Göteborg University
[2] Department of Pharmacology, Göteborg University, S-413 90 Göteborg
来源：
JOURNAL OF NEURAL TRANSMISSION | 1997年 / 104卷 / 4-5期
关键词：
MK-801; locomotion; ritanserin; M100907;
D O I：
10.1007/BF01277672
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The apparent antipsychotic action of the selective 5-HT2a receptor antagonist M100907 in MK-801-treated NMRI mice was shown to be markedly counteracted by the 5-HT2a/2c receptor antagonist ritanserin. The mechanism of action and potential implications are discussed.
引用
收藏
页码：561 / 564
页数：4
相关论文
共 50 条
  • [21] M100907, a selective 5-HT2A receptor antagonist, attenuates phencyclidine-induced Fos expression in discrete regions of rat brain
    Habara, T
    Hamamura, T
    Miki, M
    Ohashi, K
    Kuroda, S
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 417 (03) : 189 - 194
  • [22] Autoradiographic localization of 5-HT2A receptors in the human brain using L3H]M100907 and [11C]M100907
    Hall, H
    Farde, L
    Halldin, C
    Lundkvist, C
    Sedvall, G
    SYNAPSE, 2000, 38 (04) : 421 - 431
  • [23] Erratum: The Serotonin 5-HT2A Receptors Antagonist M100907 Prevents Impairment in Attentional Performance by NMDA Receptor Blockade in the Rat Prefrontal Cortex
    Mirjana Carli
    Marta Baviera
    Roberto W Invernizzi
    Claudia Balducci
    Neuropsychopharmacology, 2004, 29 : 2300 - 2300
  • [24] Synthesis and Evaluation of Dimeric Derivatives of 5-HT2A Receptor (5-HT2AR) Antagonist M-100907
    Shashack, Matthew J.
    Cunningham, Kathryn A.
    Seitz, Patricia K.
    McGinnis, Andrew
    Smith, Thressa D.
    Watson, Cheryl S.
    Gilbertson, Scott R.
    ACS CHEMICAL NEUROSCIENCE, 2011, 2 (11): : 640 - 644
  • [25] M100907, a selective 5-HT2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro
    Arvanov, VL
    Wang, RY
    NEUROPSYCHOPHARMACOLOGY, 1998, 18 (03) : 197 - 209
  • [26] M100907, A Selective 5-HT2A Receptor Antagonist and a Potential Antipsychotic Drug, Facilitates N-Methyl-D-Aspartate–Receptor Mediated Neurotransmission in the Rat Medial Prefrontal Cortical Neurons In Vitro
    Viktor L Arvanov
    Rex Y Wang
    Neuropsychopharmacology, 1998, 18 : 197 - 209
  • [27] Acute and repeated administration of the selective 5-HT2A receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons:: An in vivo electrophysiological study
    Minabe, Y
    Hashimoto, K
    Watanabe, K
    Ashby, CR
    SYNAPSE, 2001, 40 (02) : 102 - 112
  • [28] Preclinical profile of MDL 100907, a potent and selective 5-HT2A antagonist in development for schizophrenia
    Sorensen, SM
    Carr, AA
    vanGiersbergen, PLM
    Hitchcock, JM
    Kehne, JH
    Schmidt, CJ
    SCHIZOPHRENIA RESEARCH, 1996, 18 (2-3) : VIA13 - VIA13
  • [29] Determination of a specific 5-HT2a antagonist (M100907) in rat and dog plasma at the femtomole/milliliter level by gas chromatography mass spectrometry
    Emmons, GT
    Danison, TH
    Steele, D
    Sproles, GD
    JOURNAL OF CHROMATOGRAPHY B, 1998, 716 (1-2): : 161 - 169
  • [30] M100907, a highly selective 5-HT2A receptor antagonist and a potential atypical antipsychotic drug, facilitates induction of long-term potentiation in area CA1 of the rat hippocampal slice
    Wang, RY
    Arvanov, VL
    BRAIN RESEARCH, 1998, 779 (1-2) : 309 - 313
12345