Identification of a Novel HIV Type 1 Recombinant Form (CRF01_AE/CRF07_BC) in Men Who Have Sex with Men in Zhejiang, China

被引：2
|
作者：
Xu, Yufan [1 ]
Peng, Xiaorong [1 ]
Xie, Tiansheng [1 ]
Lu, Xiangyun [1 ]
Wu, Nanping [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1,State Key Lab Diag & Treatment, Collaborat Innovat Ctr Diag & Treatment Infect Di, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 07期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
HIV-1; MSM; recombinant forms; GENOMIC CHARACTERIZATION; SICHUAN;
D O I：
10.1089/aid.2017.0001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The prevalence of HIV-1 is increasing rapidly among the population of men who have sex with men (MSM) in China. Here, we report a novel HIV type 1 recombinant form consisting of CRF01_AE and CRF07_BC detected in a male patient through homosexual behavior. A phylogenic analysis revealed that this unique recombinant form (URF) exhibits a complex genomic structure with three CRF07_BC regions inserted into the CRF01_AE backbone. Recently, several second-generation recombinant forms (e.g., CRF01_AE/CRF07_BC) have been identified among MSM in China. The emergence of such URFs highlights the complexity of the HIV-1 epidemic among this population. Therefore, further molecular epidemiological investigation is required to track the genetic evolution of HIV-1 strains.
引用
收藏
页码：728 / 734
页数：7
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