A cationic derivative of amphotericin B as a novel delivery system for antisense oligonucleotides

被引：13

作者：

Garcia-Chaumont, C ^{[1
]}

Seksek, O ^{[1
]}

Jolles, B ^{[1
]}

Bolard, J ^{[1
]}

机构：

[1] Univ Paris 06, Lab Physicochim Biomol & Cellulaire, CNRS, ESA 7033, F-75252 Paris 05, France

来源：

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1089/oli.1.2000.10.177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel approach based on a plasma membrane permeability-disturbing agent was proposed as an antisense oligonucleotide delivery system. AMA, a derivative of the polyene antibiotic amphotericin B, formed a stable complex when mixed with phosphodiester oligodeoxynucleotides and enhanced the intracellular uptake of a 5' fluoresceinated anti-mdr1 20-mer into NIH-MDR-G185 cells. The nonlabeled phosphorothioate form of the oligodeoxynucleotide, complexed to AMA, inhibited P-glycoprotein expression with better efficiency and less nonspecific effects than when vectorized by Lipofectin. AMA may thus be a good agent for antisense strategy.

引用

页码：177 / 184

页数：8

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