2-O-(2-chlorobenzoyl) maslinic acid triggers apoptosis in A2780 human ovarian carcinoma cells

被引：9
|
作者：
Serbian, Immo [1 ]
Siewert, Bianka [2 ]
Al-Harrasi, Ahmed [3 ]
Csuk, Rene [1 ]
机构：
[1] Martin Luther Univ Halle Wittenberg Organ Chem, Kurt Mothes Str 2, D-06120 Halle, Saale, Germany
[2] Univ Innsbruck, Inst Pharm Pharmacognosy, CMBI, Ctr Chem & Biomed, Innrain 80-82, A-6020 Innsbruck, Austria
[3] Univ Nizwa, Nat & Med Sci Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 180卷
关键词：
Maslinic acid; Triterpenoids; Acylation; Cytotoxicity; Apoptosis; IN-VITRO; TRITERPENES; PROLIFERATION; DERIVATIVES; PATTERN;
D O I：
10.1016/j.ejmech.2019.07.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Depending on the conditions of the reactions, maslinic acid can be converted into the corresponding 2-O-, 3-O-, or 2,3-di-O-acylated compounds in good yields. These compounds showed in SRB assays a significantly increased cytotoxicity as compared to the parent compound maslinic acid. For the most active compound of this series, i.e. 2-O-(2-chlorobenzoyl) maslinic acid (5), more detailed cell biological tests (i.e. AO/PI dye exclusion experiments, an annexin V assay, and microscopic investigations) on A2780 (human ovarian carcinoma cells) revealed that this compound triggers apoptosis. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：457 / 464
页数：8
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