Association of polymorphisms of IGF1R and genes in the transforming growth factor-β bone morphogenetic protein pathway with Bacteremia in sickle cell anemia

被引：33
|
作者：
Adewoye, Adeboye H.
Nolan, Vikki G.
Ma, Qianli
Baldwin, Clinton
Wyszynski, Diego F.
Farrell, John J.
Farrer, Lindsay A.
Steinberg, Martin H.
机构：
[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02215 USA
[2] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02215 USA
[3] Boston Univ, Sch Med, Ctr Human Genet, Boston, MA 02215 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2006年 / 43卷 / 05期
关键词：
D O I：
10.1086/506356
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Infection and bacteremia are common in sickle cell disease. We hypothesized that, consistent with evidence for the genetic modulation of other disease complications, the risk of developing bacteremia might also be genetically modulated. Accordingly, we studied the association of single nucleotide polymorphisms (SNPs) in candidate genes with the risk of bacteremia in sickle cell anemia. We found significant associations with SNPs in IGF1R and genes of the TGF-beta/BMP pathway (BMP6, TGFBR3, BMPR1A, SMAD6 and SMAD3). We suggest that both IGF1R and the TGF-beta/BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a "bacteremia-prone" phenotype.
引用
收藏
页码：593 / 598
页数：6
相关论文
共 50 条
  • [31] Bone morphogenetic protein-2 and transforming growth factor-β2 interact to modulate human bone marrow stromal cell proliferation and differentiation
    Fromigué, O
    Marie, PJ
    Lomri, A
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1998, 68 (04) : 411 - 426
  • [32] Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with breast cancer in Korean women
    Kim, Mi Kyung
    Kang, Han-Sung
    Ahn, Sei Hyun
    Hong, Kyeong-Man
    Mishra, Siddhartha Kumar
    Shin, Kyung Hwan
    Ro, Jungsil
    Lee, Keun Seok
    Kim, Seok Won
    CANCER RESEARCH, 2012, 72
  • [33] α2-HS glycoprotein/fetuin, a transforming growth factor-β/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling
    Szweras, M
    Liu, DM
    Partridge, EA
    Pawling, J
    Sukhu, B
    Clokie, C
    Jahnen-Dechent, W
    Tenenbaum, HC
    Swallow, CJ
    Grynpas, MD
    Dennis, JW
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (22) : 19991 - 19997
  • [34] Transforming growth factor-β1 and bone morphogenetic protein-2 can induce bone mesenchymal stem cells to differentiate into cartilage cells
    Shi, Zhen
    Wei, Shijun
    Cai, Xianhua
    Xu, Feng
    Ding, Ran
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (05): : 4512 - 4519
  • [35] Microarray analysis of bone morphogenetic protein, transforming growth factor β, and activin early response genes during osteoblastic cell differentiation
    De Jong, DS
    Van Zoelen, EJJ
    Bauerschmidt, S
    Olijve, W
    Steegenga, WT
    JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (12) : 2119 - 2129
  • [36] Nuclear factor YY1 inhibits transforming growth factor β- and bone morphogenetic protein-induced cell differentiation
    Kurisaki, K
    Kurisaki, A
    Valcourt, U
    Terentiev, AA
    Pardali, K
    ten Dijke, P
    Heldin, CH
    Ericsson, J
    Moustakas, A
    MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (13) : 4494 - 4510
  • [37] Bone morphogenetic protein-7 is an antagonist of transforming growth factor-β2 in human trabecular meshwork cells
    Fuchshofer, Rudolf
    Yu, Alice H. L.
    Welge-Luessen, Ulrich
    Tamm, Ernst R.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (02) : 715 - 726
  • [38] Transforming Growth Factor-β and Bone Morphogenetic Protein 2 Regulation of MicroRNA-200 Family in Chronic Pancreatitis
    Yu, Peter
    Liu, Ka
    Gao, Xuxia
    Karmouty-Quintana, Harry
    Bailey, Jennifer M.
    Cao, Yanna
    Ko, Tien C.
    PANCREAS, 2018, 47 (02) : 252 - 256
  • [39] Chronic allograft nephropathy:: Intraepithelial signals generated by transforming growth factor-β and bone morphogenetic protein-7
    Tyler, JR
    Robertson, H
    Booth, TA
    Burt, AD
    Kirby, JA
    AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (06) : 1367 - 1376
  • [40] Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients
    Chinedu, Okeke
    Tonasse, Wouitchekpo Vincent
    Albuquerque, Dulcineia Martins
    Domingos, Igor de Farias
    Araujo, Aderson da Silva
    Cavalcanti Bezerra, Marcos Andre
    Sonati, Maria de Fatima
    Nunes dos Santos, Magnun Nueldo
    HEMATOLOGY TRANSFUSION AND CELL THERAPY, 2021, 43 (02) : 165 - 170
12345