A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine

被引：71

作者：

You, Longtai ^{[1
]}

Yang, Chunjing ^{[2
]}

Du, Yuanyuan ^{[1
]}

Wang, Wenping ^{[1
]}

Sun, Mingyi ^{[1
]}

Liu, Jing ^{[1
]}

Ma, Baorui ^{[1
]}

Pang, Linnuo ^{[1
]}

Zeng, Yawen ^{[1
]}

Zhang, Zhiqin ^{[1
]}

Dong, Xiaoxv ^{[1
]}

Yin, Xingbin ^{[1
]}

Ni, Jian ^{[3
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China

[2] Capital Univ Med Sci, Beijing Shijitan Hosp, Dept Pharm, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Beijing Res Inst Chinese Med, Beijing, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

matrine; pharmacology; toxicology; pharmacokinetics; mechanisms; NF-KAPPA-B; RADIX SOPHORAE TONKINENSIS; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; CANCER CELLS; STAPHYLOCOCCUS-AUREUS; DIABETIC CARDIOMYOPATHY; INHIBITS PROLIFERATION; LIQUID-CHROMATOGRAPHY; AIRWAY INFLAMMATION;

D O I：

10.3389/fphar.2020.01067

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs, such asSophora flavescensand RadixSophorae tonkinensis. Emerging evidence suggests that MT possesses anti-cancer, anti-inflammatory, anti-oxidant, antiviral, antimicrobial, anti-fibrotic, anti-allergic, antinociceptive, hepatoprotective, cardioprotective, and neuroprotective properties. These pharmacological properties form the foundation for its application in the treatment of various diseases, such as multiple types of cancers, hepatitis, skin diseases, allergic asthma, diabetic cardiomyopathy, pain, Alzheimer's disease (AD), Parkinson's disease (PD), and central nervous system (CNS) inflammation. However, an increasing number of published studies indicate that MT has serious adverse effects, the most obvious being liver toxicity and neurotoxicity, which are major factors limiting its clinical use. Pharmacokinetic studies have shown that MT has low oral bioavailability and short half-lifein vivo. This review summarizes the latest advances in research on the pharmacology, toxicology, and pharmacokinetics of MT, with a focus on its biological properties and mechanism of action. The review provides insight into the future of research on traditional Chinese medicine.

引用

页数：18

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