Tegoprazan to treat gastroesophageal reflux disease

被引：4

作者：

Mermelstein, J. ^{[1
]}

Mermelstein, A. C. ^{[2
]}

Chait, M. M. ^{[3
]}

机构：

[1] Cooper Univ Hlth Care, Dept Med, Div Gastroenterol, Camden, NJ USA

[2] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[3] Columbia Univ, Vagelos Coll Phys & Surg, Dept Med, New York, NY 10027 USA

来源：

DRUGS OF TODAY | 2020年 / 56卷 / 11期

关键词：

Gastroesophageal reflux disease (GERD); Tegoprazan; CJ-12420; Potassium-competitive acid blocker (P-CAB); Gastrointestinal disorders; Esophageal diseases; Gastric acid secretion; COMPETITIVE ACID BLOCKERS; PROTON-PUMP INHIBITORS; VONOPRAZAN; ESOMEPRAZOLE; LANSOPRAZOLE; ERADICATION; EFFICACY; UPDATE; IMPACT;

D O I：

10.1358/dot.2020.56.11.3202811

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder in the United States. Although proton pump inhibitors (PPIs) are the mainstay of therapy for GERD and its complications, they have several limitations, including incomplete symptom resolution. Potassium-competitive acid blockers (P-CABs) were developed to address the limitations of PPIs as well as the need for improved antisecretory effects. Tegoprazan, the newest P-CAB, was approved in 2018 in South Korea for the treatment of erosive esophagitis (EE) and nonerosive reflux disease (NERD). A highly selective inhibitor of the H+/K+-ATPase, tegoprazan is also safe and effective for nocturnal acid breakthrough (NAB) and motility. Further studies of tegoprazan are warranted to define its potential role in the treatment of acid-related dis-orders.

引用

页码：715 / 721

页数：7

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