Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth

被引：13
|
作者：
Kristiansen, LV [1 ]
Marques, FA [1 ]
Soroka, V [1 ]
Ronn, LCB [1 ]
Kiselyov, V [1 ]
Pedersen, N [1 ]
Berezin, V [1 ]
Bock, E [1 ]
机构：
[1] Univ Copenhagen, Panum Inst, Prot Lab, Inst Mol Pathol, DK-2200 Copenhagen N, Denmark
来源：
FEBS LETTERS | 1999年 / 464卷 / 1-2期
关键词：
cell adhesion; neurite outgrowth; L1; NCAM; interaction; Ig-module;
D O I：
10.1016/S0014-5793(99)01671-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cell adhesion molecules NCAM and L1 are considered to play key roles in neuronal development and plasticity. L1 has been shown to interact with NCAM, possibly through NCAM binding to oligomannosidic glycans present in L1, We investigated the effect of recombinant immunoglobulin (Ig) modules of NCA-IM involved in homophilic NCAM binding, on L1 induced neurite outgrowth from PC12-E2 cells and found a complete inhibition of L1 induced neurite outgrowth after addition of Ig-modules 1, 2 and 3 of NCAM, suggesting that the ligation state of NCAM is crucial for normal L1 signaling. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码：30 / 34
页数：5
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