Cyanoacetylation of 5-Aminopyrazole: Synthesis of 2-(1-Aryl-4-substituted pyrazolo[3,4-d]pyrimidin-6-yl)acetonitrile Derivatives

被引：5
|
作者：
Salaheldin, Abdellatif M. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2009年 / 64卷 / 07期
关键词：
Cyanoacetylations; Cyanopyrazoles; Pyrazolo[3,4-d]pyrimidines; Acetonitrile Derivatives; HETEROCYCLIC SYNTHESIS; ACETIC-ANHYDRIDE; ACID; PYRAZOLO<3,4-D>PYRIMIDINES; PYRAZOLOPYRIMIDINE; ANTAGONISTS; NITRILES;
D O I：
10.1515/znb-2009-0712
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
N1-Substituted-5-amino-4-cyanopyrazoles were cyanoacetylated with a mixture of cyanoacetic acid and acetic anhydride. Cyclization with POCl(3) gave 4-chloro-pyrazolo[3,4-d]pyrimidine derivatives. From the reaction with hydrazine and arylhydrazines, the hydrazinyls and their oxidized forms, the azo products, were obtained. The structure of the compounds obtained has been confirmed by 1 H and (13)C NMR spectroscopy.
引用
收藏
页码：840 / 846
页数：7
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