Validation of online functiona measures in cognitively impaired older adults

被引：20

作者：

Nosheny, Rachel L. ^{[1
,2
]}

Camacho, Monica R. ^{[2
]}

Jin, Chengshi ^{[3
]}

Neuhaus, John ^{[3
]}

Truran, Diana ^{[2
]}

Flenniken, Derek ^{[2
]}

Ashford, Miriam ^{[2
]}

Carrillo, Maria C. ^{[4
]}

Fargo, Keith N. ^{[4
]}

Hendrix, James ^{[4
]}

Hanna, Lucy ^{[5
]}

Rabinovici, Gil ^{[6
,8
]}

Maruff, Paul ^{[7
]}

Mackin, R. Scott ^{[1
,2
]}

Weiner, Michael W. ^{[2
,8
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[2] San Francisco Vet Adm Med Ctr, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[4] Alzheimers Assoc, Chicago, IL USA

[5] Brown Univ, Dept Biostat, Providence, RI 02912 USA

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[7] Cogstate Ltd, Melbourne, Vic, Australia

[8] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 10期

基金：

美国国家卫生研究院;

关键词：

activities of daily living; amyloid beta; dementia; functional decline; internet-based registry; mild cognitive impairment; study partner; subjective cognitive decline; COGSTATE BRIEF BATTERY; ALZHEIMERS ASSOCIATION WORKGROUPS; APPROPRIATE USE CRITERIA; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; EVERYDAY FUNCTION; AMYLOID PET; DEMENTIA; DISEASE; PERFORMANCE;

D O I：

10.1002/alz.12138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Assessment of functional status is associated with risk of cognitive decline and diagnosis of dementia, and can be assessed by participants and study partners (SPs). Methods: In 770 older adults enrolled in the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study and the online Brain Health Registry (BHR), we estimated associations between online assessments and clinical variables related to Alzheimer's disease (AD) risk. Results: Worse online learning scores and SP-reported functional decline were associated with higher probability of AD dementia diagnosis and poor in-clinic cognitive assessment, and with higher odds of amyloid beta (A beta) positivity when combined with participants' report of less decline. SP report of functional decline conferred predictive value independent of online cognitive assessments. Participants underreported decline compared to SPs. Discussion: The results support the validity of online assessments and their greater utilization in healthcare and research settings. Online SP-reported functional decline is an indicator of dementia and AD risk.

引用

页码：1426 / 1437

页数：12

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