Enamide-Benzyne-[2+2] Cycloaddition: Stereoselective Tandem [2+2]-Pericyclic Ring-Opening-Intramolecular N-Tethered [4+2] Cycloadditions

被引：92
|
作者：
Feltenberger, John B.
Hayashi, Ryuji
Tang, Yu
Babiash, Eric S. C.
Hsung, Richard P. [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 16期
关键词：
DIELS-ALDER REACTIONS; ELECTROCYCLIC REACTIONS; INWARD TORQUOSELECTIVITY; CATALYZED SYNTHESIS; MEDIATED SYNTHESIS; CHIRAL ENAMIDES; BENZYNE; ARYNES; SUBSTITUENT; HALIDES;
D O I：
10.1021/ol901434g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzyne-[2 + 2] cycloadditions with enamides are described. This effort led to the development of a highly stereoselective tandem [2 + 2] cycloaddition-pericyclic ring-opening-Intramolecular-N-tethered-[4 + 2] cycloaddition for rapid assembly of nitrogen heterocycles.
引用
收藏
页码：3666 / 3669
页数：4
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