Evaluation of the anti-inflammatory efficacy of Lotus corniculatus

被引：21
|
作者：
Koelzer, Janaina [1 ]
Pereira, Diana Ana [1 ]
Dalmarco, Juliana Bastos [2 ]
Pizzolatti, Moacir Geraldo [2 ]
Frode, Tania Silvia [1 ]
机构：
[1] Univ Fed Santa Catarina, Ctr Hlth Sci, Dept Clin Anal, BR-88040970 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Ctr Phys & Math Sci, Dept Chem, BR-88040970 Florianopolis, SC, Brazil
来源：
FOOD CHEMISTRY | 2009年 / 117卷 / 03期
关键词：
Lotus corniculatus; Anti-inflammatory activity; Pleurisy; Mediators of inflammation; Mice; OLEANOLIC ACID; TRITERPENOID SAPONINS; CONDENSED TANNINS; PROANTHOCYANIDINS; INHIBITION; MODEL;
D O I：
10.1016/j.foodchem.2009.04.044
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The anti-inflammatory effects of the crude extract (CE) of Lotus corniculatus var. Sao Gabriel and its derived hexane (HEX), ethyl acetate (AcOEt), n-butanol (BuOH) and aqueous (Aq) fractions and isolated compounds kaempferitrin, oleanolic acid and beta-sitosterol, in a mouse model of pleurisy induced by carrageenan were investigated. Swiss mice were used in the in vivo experiments. The crude extract of L corniculatus and its derived fractions, and also its isolated compounds, inhibited leukocytes, exudation, and myeloperoxidase (MPO) and adenosine-deaminase (ADA) activities, as well as nitrite/nitrate concentration and interleukin-1 beta (IL-1 beta) level (p < 0.05). L. corniculatus showed important anti-inflammatory activity by inhibition not only of leukocytes and/or exudation, but also of pro-inflammatory enzymes and mediators such as MPO, ADA, and IL-1 beta. The constituent's kaempferitrin, oleanolic acid and beta-sitosterol may well account for it. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：444 / 450
页数：7
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