A case report of prucalopride in pediatric gastroparesis: a novel therapy

被引：1
|
作者：
Escobar-Serna, Diana P. [1 ,2 ]
Peralta-Palmezano, Fernando J. [3 ]
Peralta-Palmezano, Juan J. [1 ,2 ]
机构：
[1] Univ Nacl Colombia, Dept Pediat, Bogota, Colombia
[2] HOMI Fdn Hosp Pediat Misericordia, Dept Pediat, Bogota, Colombia
[3] Univ Antioquia, Dept Ginecol & Obstet, Medellin, Colombia
来源：
ARCHIVOS ARGENTINOS DE PEDIATRIA | 2022年 / 120卷 / 02期
关键词：
gastroparesis; receptors serotonin; serotonin; 5-HT4; receptor agonists; gastric emptying; radionuclide imaging; STIMULATION;
D O I：
10.5546/aap.2022.eng.e98
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Prucalopride has been used in adults with gastroparesis, accelerating gastric emptying. There are no studies with this drug in gastroparetic children. An 8-year-old boy is presented who consulted for a month 01 postprandial symptoms, with a diagnosis of gastroparesis by gastric emptying scintigraphy. He did not improve with metocloprantide, domperidone, erythromycin, and esomeprazole. He received prucalopride for two periods (for 178 and 376 days) at doses: 0.03 - 0.04 mg/ kg/ day, presenting improvement in the follow-up with the cardinal gastroparesis symptom index and gastric emptying scintigraphy. Due to the good response, prucalopride may be a therapeutic option in pediatric gastroparesis.
引用
收藏
页码：E98 / E101
页数：4
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