Decline in the rate of genotypic resistance to antiretroviral drugs in recent HIV seroconverters in Madrid

被引：25
|
作者：
de Mendoza, C [1 ]
del Romero, J
Rodríguez, C
Corral, A
Soriano, V
机构：
[1] Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain
[2] Serv Reg Salud, Ctr Sanitario Sandoval, Madrid, Spain
来源：
AIDS | 2002年 / 16卷 / 13期
关键词：
D O I：
10.1097/00002030-200209060-00019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genotypic resistance to antiretroviral drugs was analysed in plasma from 57 acute or recent HIV seroconverters in Madrid. The overall prevalence of drug-associated primary resistance mutations was 25.8% in 1997-1999, but declined to 3.8% in 2000-2001. The lower rate in recent years suggested that most new HIV infections derive from viraemic individuals unaware of their HIV-positive status, rather than from those failing antiretroviral treatment. Drug-resistance testing is thus not required before beginning antiretroviral therapy.
引用
收藏
页码：1830 / 1832
页数：3
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