Decline in the rate of genotypic resistance to antiretroviral drugs in recent HIV seroconverters in Madrid

被引：25
|
作者：
de Mendoza, C [1 ]
del Romero, J
Rodríguez, C
Corral, A
Soriano, V
机构：
[1] Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain
[2] Serv Reg Salud, Ctr Sanitario Sandoval, Madrid, Spain
来源：
AIDS | 2002年 / 16卷 / 13期
关键词：
D O I：
10.1097/00002030-200209060-00019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genotypic resistance to antiretroviral drugs was analysed in plasma from 57 acute or recent HIV seroconverters in Madrid. The overall prevalence of drug-associated primary resistance mutations was 25.8% in 1997-1999, but declined to 3.8% in 2000-2001. The lower rate in recent years suggested that most new HIV infections derive from viraemic individuals unaware of their HIV-positive status, rather than from those failing antiretroviral treatment. Drug-resistance testing is thus not required before beginning antiretroviral therapy.
引用
收藏
页码：1830 / 1832
页数：3
相关论文
共 50 条
  • [1] Primary genotypic and phenotypic HIV-1 drug resistance in recent seroconverters in Madrid
    Briones, C
    Pérez-Olmeda, M
    Rodríguez, C
    del Romero, J
    Hertogs, K
    Soriano, V
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2001, 26 (02) : 145 - 150
  • [2] Changes in the rate of genotypic resistance to antiretroviral drugs in Spain
    Gallego, O
    Ruiz, L
    Vallejo, A
    Ferrer, E
    Rubio, A
    Clotet, B
    Leal, M
    Soriano, V
    [J]. AIDS, 2001, 15 (14) : 1894 - 1896
  • [3] Use of Recreational Drugs for Sex in Recent HIV Seroconverters
    Ayerdi, Oskar
    Vera, Mar
    Puerta, Teresa
    Ballesteros, Juan
    Clavo, Petunia
    Garcia, Monica
    Raposo, Montserrat
    Rodriguez, Carmen
    Del Romero, Jorge
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2018, 34 : 141 - 141
  • [4] HIV resistance to antiretroviral drugs: Mechanisms, genotypic and phenotypic resistance testing in clinical practice
    Blaise, P
    Clevenbergh, R
    Vaira, D
    Moutschen, M
    Dellamonica, P
    [J]. ACTA CLINICA BELGICA, 2002, 57 (04) : 191 - 201
  • [5] Use of genotypic assays for the detection of HIV antiretroviral resistance
    Nicastri, E
    Ippolito, G
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 : 24 - 28
  • [6] Multiple-drug antiretroviral therapy reports good HIV suppression in recent seroconverters
    不详
    [J]. AIDS PATIENT CARE AND STDS, 1996, 10 (06) : 376 - 377
  • [7] Genotypic resistance to antiretroviral drugs in patients infected with several HIV type 1 genetic forms in Cuba
    Perez, Lissette
    Alvarez, Lucia Perez
    Carmona, Rocio
    Aragones, Carlos
    Delgado, Elena
    Thomson, Michael M.
    Gonzalez, Zoila
    Contreras, Gerardo
    Perez, Jorge
    Najera, Rafael
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (03) : 407 - 414
  • [8] Genotypic resistance to antiretroviral drugs in patients with therapeutic failure to highly active antiretroviral therapy
    Gutiérrez, F
    Moltó, J
    Escolano, C
    Mora, A
    Pasquau, F
    Gregori, J
    Nogueira, E
    [J]. MEDICINA CLINICA, 2000, 115 (11): : 401 - 404
  • [9] HIV viral resistance to antiretroviral drugs: Foreword
    Ippolito, G
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 : 4 - 4
  • [10] Clinical Implications of Genotypic Resistance to the Newer Antiretroviral Drugs in HIV-1-Infected Patients with Virological Failure
    Llibre, Josep M.
    Schapiro, Jonathan M.
    Clotet, Bonaventura
    [J]. CLINICAL INFECTIOUS DISEASES, 2010, 50 (06) : 872 - 881
12345