An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

被引：80

作者：

Ali, Akbar ^{[1
]}

Correa, Arlene G. ^{[1
]}

Alves, Diego ^{[2
]}

Zukerman-Schpector, Julio ^{[1
]}

Westermann, Bernhard ^{[3
]}

Ferreira, Marco A. B. ^{[1
]}

Paixao, Marcio W. ^{[1
]}

机构：

[1] Univ Fed Sao Carlos UFSCar, Dept Chem, Sao Carlos, SP, Brazil

[2] Univ Fed Pelotas UFPel, Dept Chem, Pelotas, RS, Brazil

[3] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, Halle, Germany

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 80期

基金：

巴西圣保罗研究基金会;

关键词：

AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES; 1,3-DIPOLAR CYCLOADDITION; TERMINAL ALKYNES; REGIOSPECIFIC SYNTHESIS; TRIAZOLE FORMATION; OXIDATIVE STRESS; DIRECT ACCESS; COPPER-FREE;

D O I：

10.1039/c4cc04678a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient metal-free methodology for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles has been developed by applying a novel inverse electron-demand-1,3-dipolar cycloaddition approach. The practical one-pot metal-free strategy can be accomplished with various alkylidene malononitriles and aromatic azides in the presence of base.

引用

页码：11926 / 11929

页数：4

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