Electrophile-driven copper-catalyzed one-pot synthesis of 3-halogen quinoline derivatives

被引：7
|
作者：
Cheng, Jie [1 ]
Zhai, Hong [2 ]
Bai, Jun [1 ]
Tang, Jun [1 ]
Lv, Ling [1 ]
Sun, Bei [1 ]
机构：
[1] Anhui Prov Inst Food & Drug Control, Off Sci Res, Hefei 230022, Peoples R China
[2] Anhui Univ Chinese Med, Sch Pharm, Hefei 230031, Peoples R China
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 30期
关键词：
3-Halogen quinolines; o-Trifluoroacetyl aniline; One-pot; Tandem reaction; Copper; SUBSTITUTED QUINOLINES; ACRIDONE ALKALOIDS; CYCLIZATION; ISOQUINOLINES; 1-(2-AMINOARYL)-2-YN-1-OLS; 3-HALOQUINOLINES; QUINAZOLINE;
D O I：
10.1016/j.tetlet.2014.06.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(ll)-catalyzed cyclization-halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4044 / 4046
页数：3
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