Identification of novel 'expressed sequence tags' within the FHIT gene locus in human chromosome region 3p14.2

被引：9

作者：

Lux, A ^{[1
]}

Bardenheuer, W ^{[1
]}

Michael, D ^{[1
]}

Brocker, F ^{[1
]}

Julicher, K ^{[1
]}

Vieten, L ^{[1
]}

Michaelis, S ^{[1
]}

Seeber, S ^{[1
]}

Opalka, B ^{[1
]}

Schutte, J ^{[1
]}

机构：

[1] UNIV KLINIKEN ESSEN, WESTDEUTSCH TUMORZENTRUM, INNERE KLIN & POLIKLIN TUMORFORSCH, D-45122 ESSEN, GERMANY

来源：

HUMAN GENETICS | 1997年 / 100卷 / 01期

关键词：

D O I：

10.1007/s004390050471

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Losses of genetic material within human chromosome regions (HCR) 3p12-p14 and 3p21-p22 are observed in various neoplasias, suggesting tumor suppressor gene (TSG) loci within these regions. HCR 3p14 is particularly Interesting as it contains the t(3;8) translocation breakpoint of a hereditary renal cell carcinoma, the FRA3B fragile site, and DNA markers deleted in several types of human cancer. We here report on the identification of five novel 'expressed sequence tags' (ESTs) within 3p14.2 which map proximal to exon 9 of the candidate TSG, FHIT. These ESTs may be valuable for elucidation of the supposed TSG content in 3p14.2.

引用

页码：90 / 95

页数：6

共 50 条

[1] Identification of novel ‘expressed sequence tags’ within the FHIT gene locus in human chromosome region 3p14.2
Andreas Lux
Walter Bardenheuer
Dagmar Michael
Frank Bröcker
K. Jülicher
Lydia Vieten
Susanne Michaelis
Siegfried Seeber
Bertram Opalka
J. Schütte
[J]. Human Genetics, 1997, 100 : 90 - 95
[2] Novel tumor suppressor locus in human chromosome region 3p14.2
Jülicher, K
Marquitan, G
Werner, N
Bardenheuer, W
Vieten, L
Bröcker, F
Topal, H
Seeber, S
Opalka, B
Schütte, J
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (18) : 1563 - 1568
[3] Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene
Zimonjic, DB
Druck, T
Ohta, M
Kastury, K
Croce, CM
Popescu, NC
Huebner, K
[J]. CANCER RESEARCH, 1997, 57 (06) : 1166 - 1170
[4] The FHIT gene at 3p14.2 is abnormal in lung cancer
Sozzi, G
Veronese, ML
Negrini, M
Baffa, R
Cotticelli, MG
Inoue, H
Tornielli, S
Pilotti, S
DeGregorio, L
Pastorino, U
Pierotti, MA
Ohta, M
Huebner, K
Croce, CM
[J]. CELL, 1996, 85 (01) : 17 - 26
[5] The FHIT gene at 3p14.2 is abnormal in breast carcinomas
Negrini, M
Monaco, C
Vorechovsky, I
Ohta, M
Druck, T
Baffa, R
Huebner, K
Croce, CM
[J]. CANCER RESEARCH, 1996, 56 (14) : 3173 - 3179
[6] Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines
Yanagisawa, K
Kondo, M
Osada, H
Uchida, K
Takagi, K
Masuda, A
Takahashi, T
Takahashi, T
[J]. CANCER RESEARCH, 1996, 56 (24) : 5579 - 5582
[7] The putative tumor suppressor gene FHIT at 3p14.2 is rarely deleted in primary human brain tumors
Frank, S
Muller, J
Plaschke, J
Schackert, G
Schackert, H
[J]. 11TH INTERNATIONAL CONGRESS OF NEUROLOGICAL SURGERY, VOLS 1 AND 2, 1997, : 1723 - 1727
[8] Identification of unstable sequences within the common fragile site at 3p14.2: Implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors
Corbin, S
Neilly, ME
Espinosa, R
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[J]. CANCER RESEARCH, 2002, 62 (12) : 3477 - 3484
[9] Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus
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Delahunt, B
Grebe, SKG
[J]. CANCER RESEARCH, 1999, 59 (06) : 1323 - 1326
[10] Loss of heterozygosity at 3p14.2 (FHIT locus) and loss of FHIT protein expression are frequent events in conventional (clear cell) renal carcinoma
Moch, H
Hatz, F
Schraml, P
Bednar, R
Struckmann, K
Sauter, G
Mihatsch, MJ
[J]. MODERN PATHOLOGY, 2001, 14 (01) : 117A - 117A

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