Memory and Orientation in the Logopenic and Nonfluent Subtypes of Primary Progressive Aphasia

被引：18
|
作者：
Flanagan, Emma C. [1 ]
Tu, Sicong [1 ,2 ,3 ]
Ahmed, Samrah [4 ]
Hodges, John R. [1 ,2 ,3 ]
Hornberger, Michael [1 ,2 ,3 ,5 ]
机构：
[1] Neurosci Res Australia, Sydney, NSW, Australia
[2] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia
[3] Australian Res Council Ctr Excellence Cognit & It, Sydney, NSW, Australia
[4] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
[5] Univ Cambridge, Dept Clin Neurosci, Cambridge, England
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 40卷 / 01期
关键词：
Memory; orientation; PiB; PPA; lv-PPA; na-PPA; DIAGNOSIS; CRITERIA; DEMENTIA; DISEASE; SPEECH;
D O I：
10.3233/JAD-131448
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.
引用
下载
收藏
页码：33 / 36
页数：4
相关论文
共 50 条
  • [1] Primary progressive aphasia: primary nonfluent aphasia or logopenic aphasia? A case report
    Gawel, Malgorzata
    Domitrz, Izabela
    NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2009, 43 (04) : 382 - 387
  • [2] Motor speech disorders in the nonfluent, semantic and logopenic variants of primary progressive aphasia
    Staiger, Anja
    Schroeter, Matthias L.
    Ziegler, Wolfram
    Schoelderle, Theresa
    Anderl-Straub, Sarah
    Danek, Adrian
    Duning, Thomas
    Fassbender, Klaus
    Fliessbach, Klaus
    Jahn, Holger
    Kasper, Elisabeth
    Kornhuber, Johannes
    Landwehrmeyer, Bernhard
    Lauer, Martin
    Lombardi, Jolina
    Ludolph, Albert
    Mueller-Sarnowski, Felix
    Polyakova, Maryna
    Prix, Catharina
    Prudlo, Johannes
    Regenbrecht, Frank
    Rossmeier, Carola
    Schneider, Anja
    Wiltfang, Jens
    Otto, Markus
    Diehl-Schmid, Janine
    CORTEX, 2021, 140 : 66 - 79
  • [3] The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants
    Michael F. Bonner
    Sharon Ash
    Murray Grossman
    Current Neurology and Neuroscience Reports, 2010, 10 : 484 - 490
  • [4] The New Classification of Primary Progressive Aphasia into Semantic, Logopenic, or Nonfluent/Agrammatic Variants
    Bonner, Michael F.
    Ash, Sharon
    Grossman, Murray
    CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2010, 10 (06) : 484 - 490
  • [5] Logopenic and Nonfluent Variants of Primary Progressive Aphasia Are Differentiated by Acoustic Measures of Speech Production
    Ballard, Kirrie J.
    Savage, Sharon
    Leyton, Cristian E.
    Vogel, Adam P.
    Hornberger, Michael
    Hodges, John R.
    PLOS ONE, 2014, 9 (02):
  • [6] Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia
    Haley, Katarina L.
    Jacks, Adam
    Jarrett, Jordan
    Ray, Taylor
    Cunningham, Kevin T.
    Gorno-Tempini, Maria Luisa
    Henry, Maya L.
    JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 2021, 64 (03): : 754 - 775
  • [7] Apraxia of Speech and Phonological Errors in the Diagnosis of Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia
    Croot, Karen
    Ballard, Kirrie
    Leyton, Cristian E.
    Hodges, John R.
    JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 2012, 55 (05): : S1562 - S1572
  • [8] Logopenic Variant of the Primary Progressive Aphasia
    Brauer, Thomas
    SPRACHE-STIMME-GEHOR, 2018, 42 (04): : 160 - 161
  • [9] The logopenic variant of primary progressive aphasia
    Henry, Maya L.
    Gorno-Tempini, Maria Luisa
    CURRENT OPINION IN NEUROLOGY, 2010, 23 (06) : 633 - 637
  • [10] Distinguishing logopenic from semantic & nonfluent variant primary progressive aphasia: Patterns of linguistic and behavioral correlations
    Keator, Lynsey M.
    Wright, Amy E.
    Saxena, Sadhvi
    Kim, Kevin
    Demsky, Cornelia
    Sebastian, Rajani
    Sheppard, Shannon M.
    Breining, Bonnie
    Hillis, Argye E.
    Tippett, Donna C.
    NEUROCASE, 2019, 25 (3-4) : 98 - 105
12345