Distinguishing logopenic from semantic & nonfluent variant primary progressive aphasia: Patterns of linguistic and behavioral correlations

被引：6
|
作者：
Keator, Lynsey M. [1 ]
Wright, Amy E. [1 ]
Saxena, Sadhvi [1 ]
Kim, Kevin [1 ]
Demsky, Cornelia [1 ]
Sebastian, Rajani [1 ]
Sheppard, Shannon M. [1 ]
Breining, Bonnie [1 ]
Hillis, Argye E. [1 ,2 ,3 ]
Tippett, Donna C. [1 ,3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Dept Cognit Sci, Krieger Sch Arts & Sci, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD USA
[4] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA
来源：
NEUROCASE | 2019年 / 25卷 / 3-4期
基金：
美国国家卫生研究院;
关键词：
Primary progressive aphasia; logopenic variant primary progressive aphasia; semantic variant primary progressive aphasia; nonfluent agrammatic primary progressive aphasia; language symptoms; behavior; FRONTOTEMPORAL LOBAR DEGENERATION; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; DEMENTIA; PATHOLOGY; LANGUAGE; EVOLUTION; CLASSIFICATION; INVENTORY; DIAGNOSIS;
D O I：
10.1080/13554794.2019.1625929
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
While language characteristics of logopenic variant primary progressive aphasia (lvPPA) are well-defined, behavioral characteristics are less understood. We investigated correlations between language and behavioral scores across three variants of primary progressive aphasia (PPA) and found language performance and behavioral disturbances are correlated in lvPPA, but not other PPA subtypes. Results suggest that unlike other PPA variants, patients diagnosed with lvPPA do not develop negative behaviors until language deficits are severe. This is consistent with the underlying neuropathology of lvPPA, Alzheimer's Disease. Such findings are crucial to clinical prognosis, especially when considering the progressive nature of this disease.
引用
收藏
页码：98 / 105
页数：8
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