Copper Promoted Regio- and Stereoselective Aminochlorination of Alkynes and Alkenes with NFSI

被引：24
|
作者：
Wang, Weilin [1 ,2 ]
Liu, Lingyan [1 ,2 ]
Chang, Weixing [1 ,2 ]
Li, Jing [1 ,2 ,3 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Weijin Rd 94, Tianjin 300071, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 34期
关键词：
alkenes; alkynes; aminochlorination; chloroenamine; NFSI; NITROGEN-CENTERED RADICALS; ELECTROPHILIC DIAMINATION; AMINOHALOGENATION REACTION; CINNAMIC ESTERS; BROMINE SOURCES; HALOGEN SOURCES; OLEFINS; AMINOBROMINATION; TRIFLUOROMETHYLATION; COMPLEX;
D O I：
10.1002/chem.201801262
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and rapid copper-promoted aminochlorination of unactivated alkynes and alkenes with N-fluorobenzenesulfonimide (NFSI) was developed. Two series of chloroenamines and chloroamines were obtained in good to high yields. The chlorinated enamines could be obtained in a single Econfiguration. This reaction involved a radical process and the CuCl2 acted as the Cl source and NFSI as the N source.
引用
收藏
页码：8542 / 8547
页数：6
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