Hantzsch reaction of 3-(2-bromoacetyl)-4-hydroxy-chromen-2-one. Synthesis of 3-(thiazol-4-yl)-4-hydroxy coumarines

被引：25
|
作者：
Sukdolak, S [1 ]
Soluji, S
Manojlovic, N
Vukovic, N
Krstic, L
机构：
[1] Univ Kragujevac, Fac Sci, Dept Chem, YU-34000 Kragujevac, Serbia Monteneg, Serbia
[2] ICTM, Ctr Chem, YU-11001 Belgrade, Serbia Monteneg, Serbia
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 04期
关键词：
D O I：
10.1002/jhet.5570410418
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Acetyl-4-hydroxy-chromen-2-one (1) was brominated with phenyltrimethylammonium tribromide to afford 3-(2-bromoacetyl)-4-hydroxy-chromen-2-one (2) whose reactions with thiourea, thioacetamide and ammonium dithiocarbamate gave respectively 3 - (2-amino-thiazol-4-yl)-4-hydroxy-, 4-hydroxy-3-(2-phenyl-thiazol-4-yl)- and 4-hydroxy-3-(2-mercapto-thiazol-4-yl)chromen-2-one. In a similar manner, compound 2 was treated with four 1-substituted-2-thioureas and thiobenzamide to give the corresponding 4-hydroxy-3-(thiazol-4-yl)-chromen-2-one derivatives.
引用
收藏
页码：593 / 596
页数：4
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