Inhibitory factors of serum opsonic activity in serum from patients with chronic renal failure

被引：4
|
作者：
Kikuchi, T
Nigawara, K
Sugawara, K
Nakaji, S
Abe, T
Satoh, H
机构：
[1] Department of Hygiene, Hirosaki University, School of Medicine, Aomori
[2] OYOKYO Kidney Research Institute, Hirosaki Hospital, Aomori
[3] Department of Hygiene, Hirosaki University, School of Medicine, Hirosaki, Aomori 036
来源：
RENAL FAILURE | 1997年 / 19卷 / 01期
关键词：
D O I：
10.3109/08860229709026268
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the mechanism of impaired serum opsonic activity in patients suffering from chronic renal failure (CRF). Prehemodialysis pooled serum from CRF patients was fractionated using Sephadex G-50 gel chromatography, and the effects of the obtained fractions on serum opsonic activity were examined using luminal-dependent chemiluminescence responses. Number 25-30 fractions in the prehemodialysis serum contained factors that may inhibit serum opsonic activity. The presumed molecular weight of these fractions is between 300 and 2800 daltons. These findings indicate that the inhibitory factors of serum opsonic activity may belong to middle molecules.
引用
收藏
页码：137 / 144
页数：8
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