Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes

被引：21
|
作者：
Raffield, Laura M. [1 ,2 ,3 ]
Brenes, Gretchen A. [4 ]
Cox, Amanda J. [2 ,3 ,5 ]
Freedman, Barry I. [6 ]
Hugenschmidt, Christina E. [7 ]
Hsu, Fang-Chi [8 ]
Xu, Jianzhao [2 ,3 ]
Wagner, Benjamin C. [9 ]
Williamson, Jeff D. [7 ]
Maldjian, Joseph A. [9 ]
Bowden, Donald W. [2 ,3 ,5 ]
机构：
[1] Wake Forest Sch Med, Mol Genet & Genom Program, Winston Salem, NC 27157 USA
[2] Wake Forest Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA
[3] Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC 27157 USA
[4] Wake Forest Sch Med, Dept Psychiat & Behav Med, Winston Salem, NC 27157 USA
[5] Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27157 USA
[6] Wake Forest Sch Med, Dept Internal Med Nephrol, Winston Salem, NC 27157 USA
[7] Wake Forest Sch Med, Dept Gerontol & Geriatr, Winston Salem, NC 27157 USA
[8] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA
[9] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC 27157 USA
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2016年 / 30卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Type; 2; diabetes; Anxiety; Depression; Cognition; Magnetic resonance imaging; RISK; ADULTS; DISEASE; INFLAMMATION; METAANALYSIS; DYSFUNCTION; DISORDERS; DEMENTIA; MELLITUS; MEN;
D O I：
10.1016/j.jdiacomp.2015.09.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims: Anxiety, depression, accelerated cognitive decline, and increased risk of dementia are observed in individuals with type 2 diabetes. Anxiety and depression may contribute to lower performance on cognitive tests and differences in neuroimaging observed in individuals with type 2 diabetes. Methods: These relationships were assessed in 655 European Americans with type 2 diabetes from 504 Diabetes Heart Study families. Participants completed cognitive testing, brain magnetic resonance imaging, the Brief Symptom Inventory Anxiety subscale, and the Center for Epidemiologic Studies Depression-10. Results: In analyses adjusted for age, sex, educational attainment, and use of psychotropic medications, individuals with comorbid anxiety and depression symptoms had lower performance on all cognitive testing measures assessed (p <= 0.005). Those with both anxiety and depression also had increased white matter lesion volume (p = 0.015), decreased gray matter cerebral blood flow (p = 4.43 x 10(-6)), decreased gray matter volume (p = 0.002), increased white and gray matter mean diffusivity (p <= 0.001), and decreased white matter fractional anisotropy (p = 7.79 x 10(-4)). These associations were somewhat attenuated upon further adjustment for health status related covariates. Conclusions: Comorbid anxiety and depression symptoms were associated with cognitive performance and brain structure in a European American cohort with type 2 diabetes. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：143 / 149
页数：7
相关论文
共 50 条
  • [21] Sex Differences in the Association Between Depression, Anxiety, and Type 2 Diabetes Mellitus
    Demmer, Ryan T.
    Gelb, Sara
    Suglia, Shakira F.
    Keyes, Katherine M.
    Aiello, Allison E.
    Colombo, Paolo C.
    Galea, Sandro
    Uddin, Monica
    Koenen, Karestan C.
    Kubzansky, Laura D.
    PSYCHOSOMATIC MEDICINE, 2015, 77 (04): : 467 - 477
  • [22] Amygdala connectivity mediates the association between anxiety and depression in type 2 diabetes
    He, C.
    DIABETOLOGIA, 2019, 62 : S405 - S405
  • [23] Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Labad, J.
    Price, J. F.
    Strachan, M. W. J.
    Fowkes, F. G. R.
    Ding, J.
    Deary, I. J.
    Lee, A. J.
    Frier, B. M.
    Seckl, J. R.
    Walker, B. R.
    Reynolds, R. M.
    DIABETOLOGIA, 2010, 53 (03) : 467 - 471
  • [24] Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    J. Labad
    J. F. Price
    M. W. J. Strachan
    F. G. R. Fowkes
    J. Ding
    I. J. Deary
    A. J. Lee
    B. M. Frier
    J. R. Seckl
    B. R. Walker
    R. M. Reynolds
    Diabetologia, 2010, 53 : 467 - 471
  • [25] Testing causality in the association between regular exercise and symptoms of anxiety and depression
    De Moor, Marleen H. M.
    Boomsma, Dorret I.
    Stubbe, Janine H.
    Willemsen, Gonneke
    de Geus, Eco J. C.
    ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (08) : 897 - 905
  • [26] Associations between plasma markers and symptoms of anxiety and depression in patients with breast cancer
    Yibo He
    Shangping Cheng
    Lingrong Yang
    Lingyu Ding
    Yidan Chen
    Jing Lu
    Ruzhen Zheng
    BMC Psychiatry, 24 (1)
  • [27] Prevalence of anxiety and depression symptoms in pregnant women with type 2 diabetes and the impact on glycaemic control
    Asbjornsdottir, Bjorg
    Vestgaard, Marianne
    Do, Nicoline C.
    Ringholm, Lene
    Andersen, Lise L. T.
    Jensen, Dorte M.
    Damm, Peter
    Mathiesen, Elisabeth R.
    DIABETIC MEDICINE, 2021, 38 (03)
  • [28] Symptoms of Depression and Anxiety in Patients With Type 2 Diabetes in a Canadian Outpatient Cardiac Rehabilitation Program
    Moran, Chelsea
    Flynn, Michelle
    Campbell, Tavis
    Rouleau, Codie
    Arena, Ross
    Chirico, Daniele
    Aggarwal, Sandeep
    Laddu, Deepika
    JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION, 2021, 41 (05) : 328 - 335
  • [29] IS PSYCHOLOGICAL DISTRESS, DEPRESSION AND GENERALISED ANXIETY ASSOCIATED WITH GASTROINTESTINAL SYMPTOMS IN TYPE 2 DIABETES MELLITUS?
    Bener, A.
    EUROPEAN PSYCHIATRY, 2011, 26
  • [30] The effects of the eCoFit RCT on depression and anxiety symptoms among adults with or at risk of Type 2 Diabetes
    Wilczynska, Magdalena
    Lubans, David R.
    Plotnikoff, Ronald C.
    PSYCHOLOGY HEALTH & MEDICINE, 2022, 27 (07) : 1421 - 1430
12345