Synthesis of salvinorin A analogues as opioid receptor probes

被引：50

作者：

Tidgewell, Kevin

Harding, Wayne W.

Lozama, Anthony

Cobb, Howard

Shah, Kushal

Kannan, Pavitra

Dersch, Christina M.

Parrish, Damon

Deschamps, Jeffrey R.

Rothman, Richard B.

Prisinzano, Thomas E. ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[2] NIDA, Clin Psychopharmacol Sect, IRP, NIH,DHHS, Baltimore, MD 21224 USA

[3] USN, Res Lab, Washington, DC USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 06期

关键词：

D O I：

10.1021/np060094b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Several neoclerodanes, such as salvinorin A (1) and herkinorin (3), have recently been shown to possess opioid receptor activity in vitro and in vivo. To explore the structure-affinity relationships of this interesting class of compounds, we have synthesized a series of analogues from 1 isolated from Salvia divinorum. Here, we report the semisynthesis of neoclerodane diterpenes and their structure-affinity relationships at opioid receptors. This work will allow the further development of novel opioid receptor ligands.

引用

页码：914 / 918

页数：5

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