Embryonic stem cell-specific signature in cervical cancer

被引：25
|
作者：
Organista-Nava, Jorge [1 ,2 ]
Gomez-Gomez, Yazmin [1 ,2 ]
Gariglio, Patricio [2 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
[2] IPN, Ctr Invest & Estudios Avanzados, Dept Genet & Biol Mol, Mexico City 07360, DF, Mexico
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 03期
关键词：
Cancer stem cells; Cervical cancer; Human papillomavirus; Squamous cell carcinoma; Transcription factors; ES cell markers in cervical cancer cells; GENE-EXPRESSION SIGNATURE; TRANSCRIPTION FACTOR; BREAST-CANCER; SELF-RENEWAL; PROSPECTIVE IDENTIFICATION; SQUAMOCOLUMNAR JUNCTION; CONSTITUTIVE ACTIVATION; HUMAN ENDOMETRIAL; STAT3; ACTIVATION; ONCOGENE ZNF217;
D O I：
10.1007/s13277-013-1321-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The wide range of invasive and noninvasive lesion phenotypes associated with high-risk human papillomavirus (HR-HPV) infection in cervical cancer (CC) indicates that not only the virus but also specific cervical epithelial cells in the transformation zone (TZ), such as stem cells (SCs), play an important part in the development of cervical neoplasia. In this review, we focused in an expression signature that is specific to embryonic SCs and to poorly differentiated cervical malignant tumors and we hypothesize that this expression signature may play an important role to promote cell growth, survival, colony formation, lack of adhesion, as well as cell invasion and migration in CC.
引用
收藏
页码：1727 / 1738
页数：12
相关论文
共 50 条
  • [21] Identification of stem cell-specific genes in leech
    Hohenstein, KA
    Shain, DH
    JOURNAL OF NEUROCHEMISTRY, 2003, 85 : 75 - 75
  • [22] Exploring the mechanism of cancer stem cell-specific action by salinomyclin in yeast as a model
    Siede, Wolfram
    CANCER RESEARCH, 2011, 71
  • [23] Effect of cancer stem cell-specific progerin expression on metastatic potential.
    Morgenroth, Philipp
    Sohnchen, Christoph
    Spitschak, Alf
    Puetzer, Brigitte M.
    Logotheti, Stella
    CANCER RESEARCH, 2021, 81 (13)
  • [24] An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility
    Navarro, Carmen
    Lyu, Jing
    Katsori, Anna-Maria
    Caridha, Rozina
    Elsasser, Simon J.
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [25] An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility
    Carmen Navarro
    Jing Lyu
    Anna-Maria Katsori
    Rozina Caridha
    Simon J. Elsässer
    Nature Communications, 11
  • [26] Characterization of a novel p53-regulated embryonic stem cell-specific IncRNA that safeguards pluripotency
    Jain, Abhinav K.
    Akdemir, Kadir C.
    Xi, Yuanxin
    McCarthy, Ryan L.
    Allton, Kendra
    Aronow, Bruce
    Lin, Chunru
    Li, Wei
    Yang, Liuqing
    Barton, Michelle C.
    CANCER RESEARCH, 2016, 76
  • [27] Cell-specific transcriptional signature of human immune cells in GESTALT
    Kaila, Mary
    Shapiro, Benj
    Dunn, Christopher
    Singh, Amit
    Bektas, Arsun
    Kim, Jaekwan
    Piao, Yulan
    Wood, William
    Cuong Nguyen
    Wallace, Tonya
    Mckelvey, Julia
    Zukley, Linda
    Battle, Alexis
    De, Supriyo
    Weng, Nan-Ping
    Sen, Ranjan
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [28] A new natural killer cell-specific gene signature predicting recurrence in colorectal cancer patients
    Shembrey, Carolyn
    Foroutan, Momeneh
    Hollande, Frederic
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [29] A cancer cell-specific inducer of apoptosis
    Green, Katie L.
    Brown, Craig
    Roeder, Geraldine E.
    Southgate, Thomas D.
    Gaston, Kevin
    HUMAN GENE THERAPY, 2007, 18 (06) : 547 - 561
  • [30] Isolation of stem cell-specific cDNAs from hematopoietic stem cell populations
    Orlic, D
    Laprise, SL
    Cline, AP
    Anderson, SM
    Bodine, DM
    HEMATOPOIETIC STEM CELLS: BIOLOGY AND TRANSPLANTATION, 1999, 872 : 243 - 255
12345