Embryonic stem cell-specific signature in cervical cancer

被引：25
|
作者：
Organista-Nava, Jorge [1 ,2 ]
Gomez-Gomez, Yazmin [1 ,2 ]
Gariglio, Patricio [2 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
[2] IPN, Ctr Invest & Estudios Avanzados, Dept Genet & Biol Mol, Mexico City 07360, DF, Mexico
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 03期
关键词：
Cancer stem cells; Cervical cancer; Human papillomavirus; Squamous cell carcinoma; Transcription factors; ES cell markers in cervical cancer cells; GENE-EXPRESSION SIGNATURE; TRANSCRIPTION FACTOR; BREAST-CANCER; SELF-RENEWAL; PROSPECTIVE IDENTIFICATION; SQUAMOCOLUMNAR JUNCTION; CONSTITUTIVE ACTIVATION; HUMAN ENDOMETRIAL; STAT3; ACTIVATION; ONCOGENE ZNF217;
D O I：
10.1007/s13277-013-1321-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The wide range of invasive and noninvasive lesion phenotypes associated with high-risk human papillomavirus (HR-HPV) infection in cervical cancer (CC) indicates that not only the virus but also specific cervical epithelial cells in the transformation zone (TZ), such as stem cells (SCs), play an important part in the development of cervical neoplasia. In this review, we focused in an expression signature that is specific to embryonic SCs and to poorly differentiated cervical malignant tumors and we hypothesize that this expression signature may play an important role to promote cell growth, survival, colony formation, lack of adhesion, as well as cell invasion and migration in CC.
引用
收藏
页码：1727 / 1738
页数：12
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