Solubility of Valsartan in Different Organic Solvents and Ethanol plus Water Binary Mixtures from (278.15 to 313.15) K

被引：13
|
作者：
Liu, Yan [1 ]
Wang, Jingkang [1 ]
Wang, Xiaobo [1 ]
Liu, Peng [1 ]
Pang, Fei [1 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2009年 / 54卷 / 03期
关键词：
D O I：
10.1021/je8007815
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The solubility of valsartan in pure methyl acetate, n-butyl acetate, acetonitrile, N,N-dimethylformamide, dichloromethane, chloroform, and ethanol + water binary mixtures was measured by a synthetic method over the temperature range (278.15 to 313.15) K at atmospheric pressure. The results show that the solubility of valsartan increases with increasing temperature in all six pure solvents and ethanol + water binary mixtures, and it increases with increasing mole fraction of ethanol in the binary mixtures. The experimental data were correlated using the modified Apelblat model, and the agreement with the experimental data was very good.
引用
收藏
页码：986 / 988
页数：3
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