Hemostatic Efficacy of Nanofibrous Matrix in Rat Liver Injury Model

被引：15
|
作者：
Jaiswal, Amit K. [1 ,2 ]
Chhabra, Hemlata [2 ]
Narwane, Sandipan [3 ,4 ]
Rege, Nirmala [3 ,4 ]
Bellare, Jayesh R. [1 ]
机构：
[1] Indian Inst Technol, Bombay, Maharashtra, India
[2] VIT Univ, Ctr Biomat Cellular & Mol Theranost, Vellore 632104, Tamil Nadu, India
[3] Seth GS Med Coll, Bombay, Maharashtra, India
[4] King Edward Mem Hosp, Bombay, Maharashtra, India
来源：
SURGICAL INNOVATION | 2017年 / 24卷 / 01期
关键词：
hemostasis; liver injury; electrospinning; gelatin; polycaprolactone; HEPATIC RESECTION; AGENTS; SCAFFOLDS; PROLIFERATION; GELATIN;
D O I：
10.1177/1553350616675799
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
This present study examined the hemostatic efficacy of nanofibrous matrix in a rat liver model. The nanofibrous matrix comprising gelatin and polycaprolactone was prepared by electrospinning method. Twelve animals underwent surgery and were followed-up for a month. Time taken to cease bleeding, activated partial thromboplastin time, prothrombin time, and fibrinogen concentration were measured. Histopathological examination of liver was also done of treated and control animals. All test animals showed very rapid hemostasis after application of electrospun sheet. Histopathological study showed quick recovery of liver wound in the test group as compared to the control group. The nanofibrous matrix has proven to be not only safe and effective as hemostat but has also shown its potential for liver regeneration.
引用
收藏
页码：23 / 28
页数：6
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